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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737537
Species: Homo sapiens
RGD Object: Gene
Symbol: EDNRA
Name: endothelin receptor type A
Acc ID: CHEBI:64317
Term: isoprenaline
Definition: A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Chemical ID: MESH:D007545
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EDNRAincreases expressionISOEdnra (Rattus norvegicus)6480464CTDIsoproterenol results in increased expression of EDNRA mRNA; Isoproterenol results in increased expression of EDNRA proteinPMID:18594475 PMID:20307649 PMID:27174236
EDNRAincreases expressionISOEdnra (Mus musculus)6480464CTDIsoproterenol results in increased expression of EDNRA mRNAPMID:20003209
EDNRAmultiple interactionsISOEdnra (Rattus norvegicus)6480464CTDCPU0213 inhibits the reaction [Isoproterenol results in increased expression of EDNRA mRNA]; CPU0213 inhibits the reaction [Isoproterenol results in increased expression of EDNRA protein]; natakalim inhibits the reaction [Isoproterenol results in increased expression of EDNRA protein]; pimagedine inhibits the reaction [Isoproterenol results in increased expression of EDNRA mRNA]PMID:18594475 PMID:20307649 PMID:27174236
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