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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737520
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp19a1
Name: cytochrome P450, family 19, subfamily a, polypeptide 1
Acc ID: CHEBI:9753
Term: troglitazone
Definition: A chromane that has formula C24H27NO5S.
Chemical ID: MESH:C057693
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp19a1decreases activityISOCYP19A1 (Homo sapiens)6480464CTDtroglitazone results in decreased activity of CYP19A1 proteinPMID:10814527
Cyp19a1decreases expressionISOCYP19A1 (Homo sapiens)6480464CTDtroglitazone results in decreased expression of CYP19A1 mRNAPMID:10814527
Cyp19a1decreases expressionISOCyp19a1 (Rattus norvegicus)6480464CTDtroglitazone results in decreased expression of CYP19A1 mRNAPMID:12706301
Cyp19a1multiple interactionsISOCYP19A1 (Homo sapiens)6480464CTDLG 100268 promotes the reaction [troglitazone results in decreased activity of CYP19A1 mRNA]; LG 100268 promotes the reaction [troglitazone results in decreased activity of CYP19A1 protein]; troglitazone promotes the reaction [LG 100268 results in decreased activity of CYP19A1 mRNA]; troglitazone promotes the reaction [LG 100268 results in decreased activity of CYP19A1 protein]PMID:10814527
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