GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp19a1 | decreases expression | ISO | Cyp19a1 (Rattus norvegicus) | 6480464 | CTD | Alitretinoin results in decreased expression of CYP19A1 mRNA | PMID:12706301 | Cyp19a1 | increases expression | ISO | CYP19A1 (Homo sapiens) | 6480464 | CTD | Alitretinoin results in increased expression of CYP19A1 mRNA | PMID:15941851 | Cyp19a1 | multiple interactions | ISO | CYP19A1 (Homo sapiens) | 6480464 | CTD | [Alitretinoin binds to and results in increased activity of RXRA protein] which results in increased expression of CYP19A1 protein; Alitretinoin inhibits the reaction [NR5A2 protein promotes the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP19A1 mRNA]]; Alitretinoin inhibits the reaction [NR5A2 protein results in increased expression of CYP19A1 mRNA] | PMID:15941851 PMID:16357189 | Cyp19a1 | multiple interactions | ISO | Cyp19a1 (Rattus norvegicus) | 6480464 | CTD | Alitretinoin promotes the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of CYP19A1 mRNA] | PMID:12706301 | | ||||||||||||||||||||||
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