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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737520
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp19a1
Name: cytochrome P450, family 19, subfamily a, polypeptide 1
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp19a1decreases activityISOCYP19A1 (Homo sapiens)6480464CTDresveratrol analog results in decreased activity of CYP19A1 protein; resveratrol metabolite results in decreased activity of CYP19A1 protein; resveratrol results in decreased activity of CYP19A1 proteinPMID:16611627 PMID:17766065 PMID:17910019 PMID:20527891 PMID:27159630
Cyp19a1decreases expressionISOCYP19A1 (Homo sapiens)6480464CTDresveratrol results in decreased expression of CYP19A1 mRNAPMID:16611627 PMID:17766065
Cyp19a1increases expressionISOCYP19A1 (Homo sapiens)6480464CTDresveratrol analog results in increased expression of CYP19A1 mRNAPMID:24610083
Cyp19a1increases expressionISOCyp19a1 (Rattus norvegicus)6480464CTDresveratrol results in increased expression of CYP19A1 mRNA; resveratrol results in increased expression of CYP19A1 proteinPMID:22357324
Cyp19a1multiple interactionsISOCYP19A1 (Homo sapiens)6480464CTDResveratrol inhibits the reaction [Dinoprostone results in increased expression of CYP19A1 protein]; Resveratrol inhibits the reaction [Estradiol promotes the reaction [ESR1 results in increased expression of CYP19A1 mRNA alternative form]]; Resveratrol inhibits the reaction [Estradiol promotes the reaction [ESR1 results in increased expression of CYP19A1 protein]]; Resveratrol inhibits the reaction [Estradiol results in increased expression of CYP19A1 mRNA alternative form]; Resveratrol inhibits the reaction [Estradiol results in increased expression of CYP19A1 protein]; Resveratrol inhibits the reaction [MAPK3 results in increased expression of CYP19A1 protein]PMID:18462857 PMID:30409902
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