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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737520
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp19a1
Name: cytochrome P450, family 19, subfamily a, polypeptide 1
Acc ID: CHEBI:16422
Term: androst-4-ene-3,17-dione
Definition: A 3-oxo Delta(4)-steroid that is androst-4-ene substituted by oxo groups at positions 3 and 17. It is a steroid hormone synthesized in the adrenal glands and gonads.
Chemical ID: MESH:D000735
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp19a1affects metabolic processingISOCYP19A1 (Homo sapiens)6480464CTDCYP19A1 protein affects the metabolism of AndrostenedionePMID:12628686 PMID:16030167 PMID:16033851 PMID:16054388
Cyp19a1decreases expressionISOCyp19a1 (Rattus norvegicus)6480464CTDAndrostenedione results in decreased expression of CYP19A1 mRNAPMID:21439382
Cyp19a1increases expressionISOCyp19a1 (Rattus norvegicus)6480464CTDAndrostenedione results in increased expression of CYP19A1 mRNAPMID:21273442
Cyp19a1increases metabolic processingISOCYP19A1 (Homo sapiens)6480464CTDCYP19A1 protein results in increased metabolism of AndrostenedionePMID:22120136 PMID:26162595
Cyp19a1increases metabolic processingISOCyp19a1 (Rattus norvegicus)6480464CTDCYP19A1 protein results in increased metabolism of AndrostenedionePMID:16569475
Cyp19a1multiple interactionsISOCYP19A1 (Homo sapiens)6480464CTD2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane inhibits the reaction [CYP19A1 protein results in increased metabolism of Androstenedione]; [Fluconazole results in decreased activity of CYP19A1 protein] which results in decreased metabolism of Androstenedione; [Ketoconazole results in increased activity of CYP19A1 protein] which results in increased metabolism of Androstenedione; Atrazine promotes the reaction [CYP19A1 protein results in increased metabolism of Androstenedione]; bisphenol A affects the reaction [CYP19A1 protein results in increased metabolism of Androstenedione]; CYP19A1 protein binds to and results in increased metabolism of Androstenedione; Methoxychlor affects the reaction [CYP19A1 protein results in increased metabolism of Androstenedione]; Methyltestosterone inhibits the reaction [CYP19A1 protein affects the metabolism of Androstenedione]; Nandrolone inhibits the reaction [CYP19A1 protein affects the metabolism of Androstenedione]; Testosterone inhibits the reaction [CYP19A1 protein affects the metabolism of Androstenedione]; TNF protein promotes the reaction [CYP19A1 protein affects the metabolism of Androstenedione]; trestolone inhibits the reaction [CYP19A1 protein affects the metabolism of Androstenedione]; tributyltin inhibits the reaction [CYP19A1 protein binds to and results in increased metabolism of Androstenedione]PMID:11522339 PMID:12628686 PMID:16030167 PMID:22120136 PMID:31330226
Cyp19a1multiple interactionsISOCyp19a1 (Rattus norvegicus)6480464CTD[Androstenedione results in decreased expression of CYP19A1 mRNA] which results in decreased abundance of Estradiol; bicalutamide inhibits the reaction [Androstenedione results in increased expression of CYP19A1 protein]; Finasteride promotes the reaction [Androstenedione results in increased expression of CYP19A1 mRNA]; formestane promotes the reaction [Androstenedione results in increased expression of CYP19A1 mRNA]PMID:21273442 PMID:21439382
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