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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737517
Species: Homo sapiens
RGD Object: Gene
Symbol: STAT3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:50924
Term: sorafenib
Definition: A member of the class of phenylureas that is urea in which one of the nitrogens is substituted by a 4-chloro-3-trifluorophenyl group while the other is substituted by a phenyl group which, in turn, is substituted at the para position by a [2-(methylcarbamoyl)pyridin-4-yl]oxy group.
Chemical ID: MESH:C471405
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
STAT3decreases phosphorylationEXP 6480464CTDsorafenib analog results in decreased phosphorylation of STAT3 protein; sorafenib results in decreased phosphorylation of STAT3 proteinPMID:19001435 PMID:21531053 PMID:26911335
STAT3multiple interactionsEXP 6480464CTDresveratrol promotes the reaction [sorafenib results in decreased phosphorylation of STAT3 protein]; sorafenib inhibits the reaction [Acids results in increased phosphorylation of STAT3 protein]; sorafenib inhibits the reaction [SRC protein results in increased phosphorylation of STAT3 protein]; sorafenib inhibits the reaction [Taurocholic Acid results in increased phosphorylation of STAT3 protein]; sorafenib inhibits the reaction [TGFB1 protein results in increased phosphorylation of STAT3 protein]; sorafenib results in decreased phosphorylation of and results in decreased activity of STAT3 proteinPMID:18512153 PMID:20881478 PMID:21360571 PMID:26911335
STAT3affects localizationISOStat3 (Mus musculus)6480464CTDsorafenib affects the localization of STAT3 proteinPMID:21360571
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