GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | STAT3 | increases expression | EXP | | 6480464 | CTD | Glucose results in increased expression of STAT3 protein; Glucose results in increased expression of STAT3 protein modified form | PMID:24064760 | STAT3 | multiple interactions | EXP | | 6480464 | CTD | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of STAT3 protein modified form]]; resveratrol inhibits the reaction [Glucose results in increased expression of STAT3 protein modified form] | PMID:24064760 | STAT3 | decreases phosphorylation | ISO | Stat3 (Rattus norvegicus) | 6480464 | CTD | Glucose results in decreased phosphorylation of STAT3 protein | PMID:24810525 | STAT3 | multiple interactions | ISO | Stat3 (Rattus norvegicus) | 6480464 | CTD | [Oxygen deficiency co-treated with Glucose deficiency co-treated with Oxygen] results in increased expression of STAT3 mRNA; [Oxygen deficiency co-treated with Glucose deficiency co-treated with Oxygen] results in increased expression of STAT3 protein; cobaltiprotoporphyrin inhibits the reaction [Glucose results in decreased phosphorylation of STAT3 protein]; HMOX1 protein affects the reaction [Propofol inhibits the reaction [Glucose results in decreased phosphorylation of STAT3 protein]]; Propofol inhibits the reaction [Glucose results in decreased phosphorylation of STAT3 protein]; Resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency co-treated with Oxygen] results in increased expression of STAT3 mRNA]; Resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency co-treated with Oxygen] results in increased expression of STAT3 protein]; STAT3 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased cleavage of CASP3 protein]]; STAT3 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of ACTA1 mRNA]]; STAT3 protein affects the reaction [Propofol inhibits the reaction [Glucose results in increased expression of NPPA mRNA]]; zinc protoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Glucose results in decreased phosphorylation of STAT3 protein]]; zinc protoporphyrin inhibits the reaction [Propofol inhibits the reaction [Glucose results in decreased phosphorylation of STAT3 protein]] | PMID:23421680 PMID:24810525 | STAT3 | multiple interactions | ISO | Stat3 (Mus musculus) | 6480464 | CTD | [[[Oxygen deficiency co-treated with Glucose deficiency] co-treated with Oxygen] inhibits the reaction [IL6RA protein binds to IL6ST protein]] promotes the reaction [IL6ST protein binds to and results in increased phosphorylation of STAT3 protein]; [[Oxygen deficiency co-treated with Glucose deficiency] co-treated with Oxygen] results in decreased phosphorylation of STAT3 protein; IL6 protein inhibits the reaction [[[Oxygen deficiency co-treated with Glucose deficiency] co-treated with Oxygen] results in decreased phosphorylation of STAT3 protein]; STAT3 gene mutant form inhibits the reaction [IL22 protein results in decreased abundance of Glucose] | PMID:21940958 PMID:26064446 | | ||||||||||||||||||||||
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