GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | STAT3 | increases phosphorylation | EXP | | 6480464 | CTD | Oxygen deficiency results in increased phosphorylation of STAT3 protein; Oxygen results in increased phosphorylation of STAT3 protein | PMID:19587783 PMID:20153296 PMID:29685624 | STAT3 | multiple interactions | EXP | | 6480464 | CTD | [Digitoxin co-treated with Oxygen deficiency] results in decreased expression of and results in decreased phosphorylation of STAT3 protein; [Oxygen deficiency co-treated with alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide] results in decreased phosphorylation of STAT3 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide promotes the reaction [Folic Acid inhibits the reaction [Oxygen deficiency results in increased phosphorylation of STAT3 protein]]; Apigenin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of STAT3 protein]; fisetin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of STAT3 protein]; Folic Acid inhibits the reaction [Oxygen deficiency results in increased phosphorylation of STAT3 protein]; galangin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of STAT3 protein]; Quercetin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of STAT3 protein] | PMID:20153296 PMID:29685624 PMID:34717917 | STAT3 | increases phosphorylation | ISO | Stat3 (Mus musculus) | 6480464 | CTD | Oxygen results in increased phosphorylation of STAT3 protein | PMID:25203536 | STAT3 | multiple interactions | ISO | Stat3 (Rattus norvegicus) | 6480464 | CTD | [Oxygen deficiency co-treated with Glucose deficiency co-treated with Oxygen] results in increased expression of STAT3 mRNA; [Oxygen deficiency co-treated with Glucose deficiency co-treated with Oxygen] results in increased expression of STAT3 protein; resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency co-treated with Oxygen] results in increased expression of STAT3 mRNA]; resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency co-treated with Oxygen] results in increased expression of STAT3 protein] | PMID:23421680 | STAT3 | multiple interactions | ISO | Stat3 (Mus musculus) | 6480464 | CTD | [[[Oxygen deficiency co-treated with Glucose deficiency] co-treated with Oxygen] inhibits the reaction [IL6RA protein binds to IL6ST protein]] promotes the reaction [IL6ST protein binds to and results in increased phosphorylation of STAT3 protein]; [[Oxygen deficiency co-treated with Glucose deficiency] co-treated with Oxygen] results in decreased phosphorylation of STAT3 protein; [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of STAT3 mRNA; cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [Oxygen results in increased phosphorylation of STAT3 protein]; IL6 protein inhibits the reaction [[[Oxygen deficiency co-treated with Glucose deficiency] co-treated with Oxygen] results in decreased phosphorylation of STAT3 protein] | PMID:21940958 PMID:25203536 PMID:30529165 | |
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