Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - TERM ANNOTATION REPORT

RGD ID: 737513
Species: Homo sapiens
RGD Object: Gene
Symbol: OPRM1
Name: opioid receptor mu 1
Acc ID: DOID:2559
Term: opiate dependence
Definition: A drug dependence that involves the continued use of opiate drugs despite despite problems related to use of the substance. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Opiate_dependency "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
OPRM1 IAGP 401827929RGDDNA:SNP:exon:118A>G (rs 1799971) (human) 
OPRM1 IAGP 401827942RGDassociated with alcohol dependence:DNA:SNP, haplotypes: :-2044C>A (human) 
OPRM1 IAGP 401827948RGDDNA:missense mutation:exon:p.N40D (118A>G) (rs 1799971) (human) 
OPRM1 IAGP 401827954RGDDNA:SNPs: :multiple 
OPRM1no_associationIAGP 401827929RGDDNA:SNP:exon:17C>T (rs 1799972) (human) 
OPRM1no_associationIAGP 401827933RGDDNA:missense mutation:exon:p.N40D (118A>G) (rs 1799971) (human) 
OPRM1susceptibilityIAGP 401901242RGDDNA:SNP: :rs9479757(human) 
OPRM1treatmentIAGP 401827937RGDDNA:SNPs: :172G>T (rs6912029), 1510G>A (rs12205732) (human)  
OPRM1treatmentIAGP 401831042RGDassociated with Chronic Pain;DNA:missense mutation:exon:p.N40D (118A>G) (rs 1799971) (human) 
OPRM1treatmentIAGP 401831043RGDDNA:SNP, haplotype:3' utr:rs10485058 (human) 
OPRM1 IDA 401827935RGDDNA:hypermethylation:promoter 
OPRM1 IDA 401831040RGDDNA:altered methylation:promoter 
OPRM1 IEP 401901596RGDprotein:decreased expression:pre-frontal cortex 
OPRM1treatmentISOOprm1 (Mus musculus)401827945RGD  
OPRM1 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: OPIOID DEPENDENCE, SUSCEPTIBILITY TO, 1PMID:11134674 PMID:11773858 PMID:11773859 PMID:15037869 PMID:15086512 PMID:16046395 PMID:16387451 PMID:16682632 PMID:16906017 PMID:19528658 PMID:9193881 PMID:9689128
Go Back to source page   Continue to Ontology report