GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | OPRM1 | increases response to substance | EXP | | 6480464 | CTD | OPRM1 gene SNP results in increased susceptibility to Cocaine | PMID:12815747 | OPRM1 | multiple interactions | EXP | | 6480464 | CTD | Cocaine affects the reaction [carfentanil binds to OPRM1 protein] | PMID:15953495 | OPRM1 | affects expression | ISO | Oprm1 (Rattus norvegicus) | 6480464 | CTD | Cocaine affects the expression of OPRM1 mRNA; Cocaine affects the expression of OPRM1 protein | PMID:10891866 PMID:15950784 PMID:18990547 | OPRM1 | affects response to substance | ISO | Oprm1 (Mus musculus) | 6480464 | CTD | OPRM1 protein affects the susceptibility to Cocaine | PMID:10803207 | OPRM1 | decreases expression | ISO | Oprm1 (Rattus norvegicus) | 6480464 | CTD | Cocaine results in decreased expression of OPRM1 mRNA | PMID:12128154 | OPRM1 | decreases response to substance | ISO | Oprm1 (Mus musculus) | 6480464 | CTD | OPRM1 gene mutant form results in decreased susceptibility to Cocaine; OPRM1 mutant form results in decreased susceptibility to Cocaine | PMID:15664692 PMID:16893609 | OPRM1 | increases activity | ISO | Oprm1 (Mus musculus) | 6480464 | CTD | Cocaine results in increased activity of OPRM1 protein | PMID:17532787 | OPRM1 | increases expression | ISO | Oprm1 (Mus musculus) | 6480464 | CTD | Cocaine deficiency results in increased expression of OPRM1 mRNA | PMID:27126842 | OPRM1 | multiple interactions | ISO | Oprm1 (Mus musculus) | 6480464 | CTD | PDYN protein affects the reaction [Cocaine results in increased activity of OPRM1 protein] | PMID:17532787 | OPRM1 | multiple interactions | ISO | Oprm1 (Rattus norvegicus) | 6480464 | CTD | [CTAP octapeptide binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [POMC protein results in increased susceptibility to Cocaine]; [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein] which results in increased susceptibility to Cocaine; CTAP octapeptide inhibits the reaction [[Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein] which results in increased susceptibility to Cocaine] | PMID:19279569 | | ||||||||||||||||||||||
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