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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737488
Species: Mus musculus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:88212
Term: lead(II) chloride
Definition: An inorganic chloride consisting of two chlorine atoms covalently bound to a central lead atom.
Chemical ID: MESH:C029891
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngdecreases expressionEXP 6480464CTDlead chloride results in decreased expression of IFNG mRNAPMID:23503628
Ifngmultiple interactionsEXP 6480464CTD[lead chloride results in increased abundance of Lead] which results in increased expression of IFNG protein; decabromobiphenyl ether promotes the reaction [[lead chloride results in increased abundance of Lead] which results in increased expression of IFNG protein]; lead chloride inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; lead chloride inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]PMID:30836164 PMID:8975779
Ifngdecreases expressionISOIFNG (Homo sapiens)6480464CTDlead chloride results in decreased expression of IFNG proteinPMID:15843504
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