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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737488
Species: Mus musculus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngaffects expressionEXP 6480464CTDAcetaminophen affects the expression of IFNG proteinPMID:27826632
Ifngdecreases expressionEXP 6480464CTDAcetaminophen results in decreased expression of IFNG mRNAPMID:37179516
Ifngincreases expressionEXP 6480464CTDAcetaminophen results in increased expression of IFNG mRNA; Acetaminophen results in increased expression of IFNG proteinPMID:12051698 PMID:12153990 PMID:14557383 PMID:15578514 PMID:17185352 PMID:19164858 PMID:19739265 PMID:29689376
Ifngmultiple interactionsEXP 6480464CTD[Clofibrate co-treated with Acetaminophen] affects the expression of IFNG mRNA; [GJA1 protein affects the susceptibility to Acetaminophen] which affects the secretion of IFNG protein; Aspirin inhibits the reaction [Acetaminophen results in increased expression of IFNG mRNA]; IFNG protein promotes the reaction [Acetaminophen results in increased expression of CCL2 mRNA]; IFNG protein promotes the reaction [Acetaminophen results in increased expression of CCL3 mRNA]; IFNG protein promotes the reaction [Acetaminophen results in increased expression of CXCL1 mRNA]; IFNG protein promotes the reaction [Acetaminophen results in increased expression of CXCL10 mRNA]; IFNG protein promotes the reaction [Acetaminophen results in increased expression of CXCL2 mRNA]; IFNG protein promotes the reaction [Acetaminophen results in increased expression of CXCL9 mRNA]; IFNG protein promotes the reaction [Acetaminophen results in increased expression of FAS mRNA]; IFNG protein promotes the reaction [Acetaminophen results in increased expression of ICAM1 mRNA]; IFNG protein promotes the reaction [Acetaminophen results in increased expression of IL1A mRNA]; IFNG protein promotes the reaction [Acetaminophen results in increased expression of IL1B mRNA]; IFNG protein promotes the reaction [Acetaminophen results in increased expression of IL6 mRNA]; IFNG protein promotes the reaction [Acetaminophen results in increased expression of NOS2 mRNA]; IFNG protein promotes the reaction [Acetaminophen results in increased expression of TNF mRNA]; IFNG protein promotes the reaction [Acetaminophen results in increased expression of VCAM1 mRNA]; KLRB1C protein promotes the reaction [Acetaminophen results in increased expression of IFNG mRNA]; manumycin inhibits the reaction [Acetaminophen results in increased expression of IFNG mRNA]; manumycin inhibits the reaction [Acetaminophen results in increased expression of IFNG protein]; Methionine inhibits the reaction [Acetaminophen results in increased expression of IFNG mRNA]; Methionine inhibits the reaction [Acetaminophen results in increased expression of IFNG protein]; PANX1 protein modified form affects the reaction [Acetaminophen affects the expression of IFNG protein]; PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of IFNG mRNA]; S100A9 protein promotes the reaction [Acetaminophen results in increased expression of IFNG mRNA]; TNFRSF1A protein promotes the reaction [Acetaminophen results in increased expression of IFNG mRNA]PMID:12051698 PMID:12153990 PMID:14557383 PMID:15578514 PMID:17585979 PMID:19164858 PMID:19739265 PMID:26912412 PMID:27826632
Ifngincreases expressionISOIfng (Rattus norvegicus)6480464CTDAcetaminophen results in increased expression of IFNG proteinPMID:18237725
Ifngmultiple interactionsISOIfng (Rattus norvegicus)6480464CTDHyaluronic Acid inhibits the reaction [Acetaminophen results in increased expression of IFNG protein]PMID:18237725
Ifngmultiple interactionsISOIFNG (Homo sapiens)6480464CTD[Acetaminophen co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNAPMID:29594315
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