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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737487
Species: Homo sapiens
RGD Object: Gene
Symbol: IFNG
Name: interferon gamma
Acc ID: CHEBI:53076
Term: 4-(ethoxymethylene)-2-phenyloxazol-5-one
Definition: A 1,3-oxazole compound having a phenyl substituent at the 2-position, an ethoxymethylene group at the 4-position, and an oxo group at the 5-position. It is a chemical allergen used for immunological experiments, particularly for experiments on delayed type hypersensitivity.
Chemical ID: MESH:D010081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IFNGincreases expressionISOIfng (Mus musculus)6480464CTDOxazolone results in increased expression of IFNG mRNA; Oxazolone results in increased expression of IFNG proteinPMID:18242016 PMID:18652873 PMID:18670081 PMID:19422874 PMID:21404309 PMID:24205293 PMID:28826779
IFNGmultiple interactionsISOIfng (Mus musculus)6480464CTD12-acetoxyhawtriwaic acid lactone inhibits the reaction [Oxazolone results in increased expression of IFNG protein]; centipedic acid inhibits the reaction [Oxazolone results in increased expression of IFNG protein]; Dexamethasone inhibits the reaction [Oxazolone results in increased expression of IFNG protein]PMID:18670081
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