GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | IFNG | decreases expression | EXP | | 6480464 | CTD | Arsenic Trioxide results in decreased expression of IFNG mRNA; Arsenic Trioxide results in decreased expression of IFNG protein | PMID:29159556 PMID:29950232 PMID:34108876 | IFNG | increases activity | EXP | | 6480464 | CTD | Arsenic Trioxide results in increased activity of IFNG protein | PMID:14668793 | IFNG | multiple interactions | EXP | | 6480464 | CTD | Arsenic Trioxide promotes the reaction [[IFNG protein results in increased activity of STAT1 protein] which results in increased expression of IRF1 mRNA]; Arsenic Trioxide promotes the reaction [IFNG protein results in increased activity of STAT1 protein]; Arsenic Trioxide promotes the reaction [IFNG protein results in increased expression of IRF1 mRNA]; Arsenic Trioxide promotes the reaction [IFNG protein results in increased expression of IRF1 protein]; Arsenic Trioxide promotes the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]; CASP3 protein promotes the reaction [Arsenic Trioxide results in increased activity of IFNG protein] | PMID:14668793 PMID:16914093 | IFNG | affects expression | ISO | Ifng (Mus musculus) | 6480464 | CTD | Arsenic Trioxide affects the expression of IFNG mRNA | PMID:19545743 | IFNG | decreases expression | ISO | Ifng (Mus musculus) | 6480464 | CTD | Arsenic Trioxide results in decreased expression of IFNG mRNA; Arsenic Trioxide results in decreased expression of IFNG protein | PMID:23802174 PMID:29049341 PMID:29159556 PMID:37166470 | IFNG | increases expression | ISO | Ifng (Rattus norvegicus) | 6480464 | CTD | Arsenic Trioxide results in increased expression of IFNG mRNA; Arsenic Trioxide results in increased expression of IFNG protein | PMID:30368975 PMID:34037972 | IFNG | multiple interactions | ISO | Ifng (Rattus norvegicus) | 6480464 | CTD | boric acid inhibits the reaction [Arsenic Trioxide results in increased expression of IFNG mRNA]; boric acid inhibits the reaction [Arsenic Trioxide results in increased expression of IFNG protein]; Phloretin inhibits the reaction [Arsenic Trioxide results in increased expression of IFNG protein] | PMID:30368975 PMID:34037972 | IFNG | multiple interactions | ISO | Ifng (Mus musculus) | 6480464 | CTD | [Arsenic Trioxide co-treated with Cyclosporine] affects the expression of IFNG mRNA | PMID:19545743 | | ||||||||||||||||||||||
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