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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737476
Species: Homo sapiens
RGD Object: Gene
Symbol: DNAJB9
Name: DnaJ heat shock protein family (Hsp40) member B9
Acc ID: CHEBI:2663
Term: amiodarone
Definition: A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.
Chemical ID: MESH:D000638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DNAJB9increases expressionEXP 6480464CTDAmiodarone results in increased expression of DNAJB9 mRNAPMID:19774075 PMID:36586010
DNAJB9increases expressionISODnajb9 (Mus musculus)6480464CTDAmiodarone results in increased expression of DNAJB9 mRNA; Amiodarone results in increased expression of DNAJB9 proteinPMID:28962527 PMID:34259586
DNAJB9multiple interactionsISODnajb9 (Mus musculus)6480464CTD1-(3,4-dihydroxyphenyl)-2-thiocyanate-ethanone inhibits the reaction [Amiodarone results in increased expression of DNAJB9 mRNA]; 4-phenylbutyric acid inhibits the reaction [Amiodarone results in increased expression of DNAJB9 mRNA]; DDIT3 gene mutant form inhibits the reaction [Amiodarone results in increased expression of DNAJB9 mRNA]PMID:28962527 PMID:34259586
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