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GENE - TERM ANNOTATION REPORT

RGD ID: 737467
Species: Homo sapiens
RGD Object: Gene
Symbol: ADRB3
Name: adrenoceptor beta 3
Acc ID: HP:0001635
Term: Congestive heart failure
Definition: The presence of an abnormality of cardiac function that is responsible for the failure of the heart to pump blood at a rate that is commensurate with the needs of the tissues or a state in which abnormally elevated filling pressures are required for the heart to do so. Heart failure is frequently related to a defect in myocardial contraction.
Definition Source(s): https://orcid.org/0000-0002-0736-9199
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ADRB3susceptibilityIAGP 5684776RGDassociated with Diabetes Mellitus, Type 2;DNA:missense mutation:cds:p.W64R (rs4994) 
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