GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cat | affects activity | EXP | | 6480464 | CTD | Cyclophosphamide affects the activity of CAT protein | PMID:20052769 PMID:22285266 | Cat | decreases activity | EXP | | 6480464 | CTD | Cyclophosphamide results in decreased activity of CAT protein | PMID:21772021 PMID:23542512 PMID:29753871 | Cat | decreases expression | EXP | | 6480464 | CTD | Cyclophosphamide results in decreased expression of CAT mRNA; Cyclophosphamide results in decreased expression of CAT protein | PMID:23542512 PMID:27633142 | Cat | multiple interactions | EXP | | 6480464 | CTD | Buthionine Sulfoximine promotes the reaction [Cyclophosphamide results in decreased activity of CAT protein]; cinnamic acid inhibits the reaction [Cyclophosphamide affects the activity of CAT protein]; Cyclophosphamide promotes the reaction [NFE2L2 gene mutant form results in decreased expression of CAT protein]; Eicosapentaenoic Acid inhibits the reaction [Cyclophosphamide affects the activity of CAT protein]; Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; NFE2L2 gene mutant form promotes the reaction [Cyclophosphamide results in decreased expression of CAT protein]; Plant Extracts inhibits the reaction [Buthionine Sulfoximine promotes the reaction [Cyclophosphamide results in decreased activity of CAT protein]]; Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased expression of CAT mRNA] | PMID:20052769 PMID:21772021 PMID:22285266 PMID:23542512 PMID:27633142 PMID:29753871 | Cat | decreases activity | ISO | Cat (Rattus norvegicus) | 6480464 | CTD | Cyclophosphamide results in decreased activity of CAT protein | PMID:16076520 PMID:20957680 PMID:23695977 PMID:25753322 PMID:33992719 PMID:34748891 PMID:35906875 | Cat | decreases expression | ISO | Cat (Rattus norvegicus) | 6480464 | CTD | Cyclophosphamide results in decreased expression of CAT protein | PMID:19107871 | Cat | multiple interactions | ISO | Cat (Rattus norvegicus) | 6480464 | CTD | mangiferin inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; naringin inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; Pentoxifylline inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; pimagedine inhibits the reaction [Cyclophosphamide results in decreased expression of CAT protein]; Quercetin inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; Rutin inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein] | PMID:16076520 PMID:19107871 PMID:20957680 PMID:23695977 PMID:25753322 PMID:33992719 PMID:34748891 PMID:35906875 | | ||||||||||||||||||||||
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