Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737448
Species: Mus musculus
RGD Object: Gene
Symbol: Cat
Name: catalase
Acc ID: CHEBI:3638
Term: chloroquine
Definition: An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Chemical ID: MESH:D002738
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Catdecreases activityEXP 6480464CTDChloroquine results in decreased activity of CAT proteinPMID:23607047
Catdecreases expressionEXP 6480464CTDChloroquine results in decreased expression of CAT mRNAPMID:23607047
Catmultiple interactionsEXP 6480464CTDChloroquine promotes the reaction [Sunitinib results in increased activity of CAT protein]; Quercetin inhibits the reaction [Chloroquine results in decreased activity of CAT protein]; Quercetin inhibits the reaction [Chloroquine results in decreased expression of CAT mRNA]PMID:23607047 PMID:24751611
Catdecreases activityISOCat (Rattus norvegicus)6480464CTDChloroquine results in decreased activity of CAT proteinPMID:17076682
Catdecreases expressionISOCat (Rattus norvegicus)6480464CTDChloroquine results in decreased expression of CAT proteinPMID:15526909
Catmultiple interactionsISOCat (Rattus norvegicus)6480464CTDCurcumin inhibits the reaction [Chloroquine results in decreased activity of CAT protein]; tetrahydrocurcumin inhibits the reaction [Chloroquine results in decreased activity of CAT protein]PMID:17076682
Go Back to source page   Continue to Ontology report