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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737448
Species: Mus musculus
RGD Object: Gene
Symbol: Cat
Name: catalase
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Catmultiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Acetaminophen results in decreased expression of CAT protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Ethanol results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [mancozeb results in decreased activity of CAT protein]; Acetylcysteine promotes the reaction [XRCC1 protein results in increased activity of CAT protein]PMID:19853593 PMID:24299490 PMID:30037311 PMID:30423402 PMID:30998386 PMID:34547296 PMID:37458150
Catdecreases activityISOCAT (Homo sapiens)6480464CTDAcetylcysteine results in decreased activity of CAT proteinPMID:24577230
Catincreases expressionISOCAT (Homo sapiens)6480464CTDAcetylcysteine results in increased expression of CAT proteinPMID:16169029
Catmultiple interactionsISOCat (Rattus norvegicus)6480464CTDAcetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Carmustine results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [chlorpyrifos-methyl results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Dichlorvos results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Diclofenac results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Dimethoate results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Dimethylnitrosamine results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Malathion results in increased activity of CAT protein]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [tributyltin results in increased expression of CAT protein]; Acetylcysteine inhibits the reaction [Zinc results in decreased expression of CAT protein]; Selenium promotes the reaction [Acetylcysteine inhibits the reaction [Mercuric Chloride results in decreased activity of CAT protein]]PMID:19840221 PMID:20332008 PMID:21114986 PMID:22416658 PMID:22427991 PMID:24485406 PMID:24810974 PMID:26079211 PMID:26769589 PMID:28535741 PMID:29143438 PMID:32402895 PMID:34425170 PMID:34767868
Catmultiple interactionsISOCAT (Homo sapiens)6480464CTD[Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Particulate Matter results in increased activity of CAT protein]; Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of CAT protein]; Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of CAT mRNA]; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of CAT mRNA]; Acetylcysteine inhibits the reaction [ceric oxide results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Chlorine results in increased expression of CAT protein]; Acetylcysteine inhibits the reaction [Chlorpyrifos affects the activity of CAT protein]; Acetylcysteine inhibits the reaction [Endosulfan results in increased activity of CAT protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Malathion results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [mancozeb results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Propofol results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Smoke analog results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Sodium Fluoride results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [tetrabromobisphenol A results in increased expression of CAT mRNA]; Acetylcysteine inhibits the reaction [TGFB1 protein results in decreased expression of CAT mRNA]; CAT protein inhibits the reaction [Acetylcysteine results in increased abundance of Hydrogen Peroxide]PMID:21131394 PMID:23416263 PMID:26257840 PMID:27235710 PMID:27246665 PMID:28012895 PMID:28013216 PMID:28108387 PMID:28804952 PMID:30769050 PMID:30951941 PMID:31157476 PMID:32023790 PMID:34856488 PMID:35065218 PMID:35430258 PMID:7491977
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