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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737443
Species: Mus musculus
RGD Object: Gene
Symbol: Gap43
Name: growth associated protein 43
Acc ID: CHEBI:35696
Term: cobalt dichloride
Definition: A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.
Chemical ID: MESH:C018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gap43increases expressionISOGap43 (Rattus norvegicus)6480464CTDcobaltous chloride results in increased expression of GAP43 mRNAPMID:18375950
Gap43increases phosphorylationISOGap43 (Rattus norvegicus)6480464CTDcobaltous chloride results in increased phosphorylation of GAP43 proteinPMID:18375950
Gap43multiple interactionsISOGap43 (Rattus norvegicus)6480464CTDAcetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of GAP43 protein]; bisindolylmaleimide inhibits the reaction [cobaltous chloride results in increased phosphorylation of GAP43 protein]; PRKCE protein promotes the reaction [cobaltous chloride results in increased phosphorylation of GAP43 protein]; Zinc inhibits the reaction [cobaltous chloride results in increased phosphorylation of GAP43 protein]PMID:18375950
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