A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID:
MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Calcitriol affects the expression of and affects the activity of CYP24A1 protein; Calcitriol promotes the reaction [CREBBP protein binds to CYP24A1 promoter]; Calcitriol promotes the reaction [EP300 protein binds to CYP24A1 promoter]; Calcitriol promotes the reaction [MED1 protein binds to CYP24A1 promoter]; Calcitriol promotes the reaction [NCOA1 protein binds to CYP24A1 promoter]; Calcitriol promotes the reaction [NCOA2 protein binds to CYP24A1 promoter]; Calcitriol promotes the reaction [NCOA3 protein binds to CYP24A1 promoter]; Calcitriol promotes the reaction [RXRA protein binds to CYP24A1 promoter]; Calcitriol promotes the reaction [VDR protein binds to CYP24A1 promoter]; Ketoconazole promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]
Calcitriol analog results in increased expression of CYP24A1; Calcitriol results in increased expression of CYP24A1; Calcitriol results in increased expression of CYP24A1 mRNA; Calcitriol results in increased expression of CYP24A1 protein
[Benzo(a)pyrene co-treated with Calcitriol] results in increased expression of CYP24A1 mRNA; [Calcitriol binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA; [Calcitriol co-treated with NR1I2 protein] results in increased expression of CYP24A1 mRNA; [Calcitriol co-treated with VDR protein] results in increased expression of CYP24A1 mRNA; [Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] which results in increased expression of CYP24A1 mRNA; [Ketoconazole results in decreased metabolism of Calcitriol] which results in increased expression of CYP24A1 mRNA; [Testosterone co-treated with Calcitriol] results in increased expression of CYP24A1 mRNA; alpha-Linolenic Acid inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [Calcitriol promotes the reaction [VDR protein binds to CYP24A1 promoter]]]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]]; alpha-naphthoflavone inhibits the reaction [Cycloheximide promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]]; Benzo(a)pyrene inhibits the reaction [Calcitriol promotes the reaction [RXRA protein binds to CYP24A1 promoter]]; Benzo(a)pyrene inhibits the reaction [Calcitriol promotes the reaction [VDR protein binds to CYP24A1 promoter]]; Benzo(a)pyrene promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; Benzo(a)pyrene promotes the reaction [CYP24A1 protein results in increased degradation of Calcitriol]; Bezafibrate inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; BMS453 inhibits the reaction [Tretinoin inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]]; Calcitriol inhibits the reaction [NCOR2 protein binds to CYP24A1 promoter]; Calcitriol promotes the reaction [[VDR protein binds to MED1 protein] which binds to CYP24A1 promoter]; Calcitriol promotes the reaction [[VDR protein binds to NCOA3 protein] which binds to CYP24A1 promoter]; Calcitriol promotes the reaction [[VDR protein binds to RXRA protein] which binds to CYP24A1 promoter]; Calcitriol promotes the reaction [HNF4A protein binds to CYP24A1 mRNA]; Calcitriol promotes the reaction [NCOA1 protein binds to CYP24A1 promoter]; Calcitriol promotes the reaction [NCOR1 protein binds to CYP24A1 mRNA]; Calcitriol promotes the reaction [NCOR2 protein binds to CYP24A1 mRNA]; Calcitriol promotes the reaction [RXRA protein binds to CYP24A1 mRNA]; Calcitriol promotes the reaction [RXRA protein binds to CYP24A1 promoter]; Calcitriol promotes the reaction [VDR protein binds to CYP24A1 mRNA]; Calcitriol promotes the reaction [VDR protein binds to CYP24A1 promoter]; CSK protein promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; Cycloheximide inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; CYP24A1 gene mutant form results in decreased metabolism of and results in increased abundance of Calcitriol; CYP24A1 protein results in increased metabolism of and results in decreased susceptibility to Calcitriol; Dihydrotestosterone inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; Docosahexaenoic Acids promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; Genistein inhibits the reaction [Calcitriol results in increased activity of CYP24A1 protein]; Genistein inhibits the reaction [CYP24A1 protein results in increased degradation of Calcitriol]; Genistein promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; GW 501516 inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; HR protein inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; Ketoconazole promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; lactacystin promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; Methylcholanthrene promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; NCOR1 protein inhibits the reaction [[Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] which results in increased expression of CYP24A1 mRNA]; NCOR2 protein inhibits the reaction [[Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] which results in increased expression of CYP24A1 mRNA]; perfluorooctanoic acid inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; PPARGC1A protein promotes the reaction [[Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] which results in increased expression of CYP24A1 mRNA]; RELA protein promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; saracatinib inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; tamibarotene inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; Tetradecanoylphorbol Acetate promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; Tretinoin inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; trichostatin A promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; trichostatin A promotes the reaction [Valproic Acid promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]]; U 0126 inhibits the reaction [Calcitriol promotes the reaction [NCOR2 protein binds to CYP24A1 mRNA]]; U 0126 inhibits the reaction [Calcitriol promotes the reaction [VDR protein binds to CYP24A1 mRNA]]; Valproic Acid promotes the reaction [[Calcitriol co-treated with VDR protein] results in increased expression of CYP24A1 mRNA]; Valproic Acid promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]
[Calcium co-treated with Calcitriol] affects the expression of CYP24A1 mRNA; [Ketoconazole co-treated with Calcitriol] results in increased expression of CYP24A1 mRNA; Ketoconazole inhibits the reaction [Calcitriol results in increased activity of CYP24A1 protein]