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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737342
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp24a1
Name: cytochrome P450, family 24, subfamily a, polypeptide 1
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp24a1affects expressionEXP 6480464CTDCalcitriol affects the expression of CYP24A1 mRNA; Calcitriol affects the expression of CYP24A1 proteinPMID:11796525 PMID:17244627
Cyp24a1increases activityEXP 6480464CTDCalcitriol results in increased activity of CYP24A1 proteinPMID:10694374
Cyp24a1increases expressionEXP 6480464CTDCalcitriol results in increased expression of CYP24A1 mRNAPMID:10694374 PMID:17035339 PMID:18840526 PMID:26704532
Cyp24a1increases response to substanceEXP 6480464CTDCYP24A1 protein results in increased susceptibility to CalcitriolPMID:17244627
Cyp24a1multiple interactionsEXP 6480464CTDCalcitriol affects the expression of and affects the activity of CYP24A1 protein; Calcitriol promotes the reaction [CREBBP protein binds to CYP24A1 promoter]; Calcitriol promotes the reaction [EP300 protein binds to CYP24A1 promoter]; Calcitriol promotes the reaction [MED1 protein binds to CYP24A1 promoter]; Calcitriol promotes the reaction [NCOA1 protein binds to CYP24A1 promoter]; Calcitriol promotes the reaction [NCOA2 protein binds to CYP24A1 promoter]; Calcitriol promotes the reaction [NCOA3 protein binds to CYP24A1 promoter]; Calcitriol promotes the reaction [RXRA protein binds to CYP24A1 promoter]; Calcitriol promotes the reaction [VDR protein binds to CYP24A1 promoter]; Ketoconazole promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]PMID:15647825 PMID:17244627 PMID:18840526
Cyp24a1affects abundanceISOCyp24a1 (Rattus norvegicus)6480464CTDCYP24A1 protein affects the abundance of CalcitriolPMID:12846736
Cyp24a1increases activityISOCYP24A1 (Homo sapiens)6480464CTDCalcitriol results in increased activity of CYP24A1 proteinPMID:15955619
Cyp24a1increases activityISOCyp24a1 (Rattus norvegicus)6480464CTDCalcitriol results in increased activity of CYP24A1 proteinPMID:16483768
Cyp24a1increases degradationISOCYP24A1 (Homo sapiens)6480464CTDCYP24A1 protein results in increased degradation of CalcitriolPMID:15955619
Cyp24a1increases expressionISOCYP24A1 (Homo sapiens)6480464CTDCalcitriol analog results in increased expression of CYP24A1; Calcitriol results in increased expression of CYP24A1; Calcitriol results in increased expression of CYP24A1 mRNA; Calcitriol results in increased expression of CYP24A1 proteinPMID:14996990 PMID:15538745 PMID:15890193 PMID:15919092 PMID:15955619 PMID:15992766 PMID:16002434 PMID:16039846 PMID:16061850 PMID:16289102 PMID:16365879 PMID:16824767 PMID:19244278 PMID:19667147 PMID:19667161 PMID:20206692 PMID:20371703 PMID:21115105 PMID:21542014 PMID:21592394 PMID:21917910 PMID:22466564 PMID:22751936 PMID:22837390 PMID:24039193 PMID:24792400 PMID:26485663 PMID:27107558 PMID:33033332 PMID:7530193
Cyp24a1increases expressionISOCyp24a1 (Rattus norvegicus)6480464CTDCalcitriol results in increased expression of CYP24A1 mRNA; Calcitriol results in increased expression of CYP24A1 proteinPMID:10927029 PMID:8164439
Cyp24a1increases metabolic processingISOCYP24A1 (Homo sapiens)6480464CTDCYP24A1 protein results in increased metabolism of CalcitriolPMID:26038696
Cyp24a1multiple interactionsISOCYP24A1 (Homo sapiens)6480464CTD[Benzo(a)pyrene co-treated with Calcitriol] results in increased expression of CYP24A1 mRNA; [Calcitriol binds to and results in increased activity of VDR protein] which results in increased expression of CYP24A1 mRNA; [Calcitriol co-treated with NR1I2 protein] results in increased expression of CYP24A1 mRNA; [Calcitriol co-treated with VDR protein] results in increased expression of CYP24A1 mRNA; [Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] which results in increased expression of CYP24A1 mRNA; [Ketoconazole results in decreased metabolism of Calcitriol] which results in increased expression of CYP24A1 mRNA; [Testosterone co-treated with Calcitriol] results in increased expression of CYP24A1 mRNA; alpha-Linolenic Acid inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [Calcitriol promotes the reaction [VDR protein binds to CYP24A1 promoter]]]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]]; alpha-naphthoflavone inhibits the reaction [Cycloheximide promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]]; Benzo(a)pyrene inhibits the reaction [Calcitriol promotes the reaction [RXRA protein binds to CYP24A1 promoter]]; Benzo(a)pyrene inhibits the reaction [Calcitriol promotes the reaction [VDR protein binds to CYP24A1 promoter]]; Benzo(a)pyrene promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; Benzo(a)pyrene promotes the reaction [CYP24A1 protein results in increased degradation of Calcitriol]; Bezafibrate inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; BMS453 inhibits the reaction [Tretinoin inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]]; Calcitriol inhibits the reaction [NCOR2 protein binds to CYP24A1 promoter]; Calcitriol promotes the reaction [[VDR protein binds to MED1 protein] which binds to CYP24A1 promoter]; Calcitriol promotes the reaction [[VDR protein binds to NCOA3 protein] which binds to CYP24A1 promoter]; Calcitriol promotes the reaction [[VDR protein binds to RXRA protein] which binds to CYP24A1 promoter]; Calcitriol promotes the reaction [HNF4A protein binds to CYP24A1 mRNA]; Calcitriol promotes the reaction [NCOA1 protein binds to CYP24A1 promoter]; Calcitriol promotes the reaction [NCOR1 protein binds to CYP24A1 mRNA]; Calcitriol promotes the reaction [NCOR2 protein binds to CYP24A1 mRNA]; Calcitriol promotes the reaction [RXRA protein binds to CYP24A1 mRNA]; Calcitriol promotes the reaction [RXRA protein binds to CYP24A1 promoter]; Calcitriol promotes the reaction [VDR protein binds to CYP24A1 mRNA]; Calcitriol promotes the reaction [VDR protein binds to CYP24A1 promoter]; CSK protein promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; Cycloheximide inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; CYP24A1 gene mutant form results in decreased metabolism of and results in increased abundance of Calcitriol; CYP24A1 protein results in increased metabolism of and results in decreased susceptibility to Calcitriol; Dihydrotestosterone inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; Docosahexaenoic Acids promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; Genistein inhibits the reaction [Calcitriol results in increased activity of CYP24A1 protein]; Genistein inhibits the reaction [CYP24A1 protein results in increased degradation of Calcitriol]; Genistein promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; GW 501516 inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; HR protein inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; Ketoconazole promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; lactacystin promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; Methylcholanthrene promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; NCOR1 protein inhibits the reaction [[Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] which results in increased expression of CYP24A1 mRNA]; NCOR2 protein inhibits the reaction [[Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] which results in increased expression of CYP24A1 mRNA]; perfluorooctanoic acid inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; PPARGC1A protein promotes the reaction [[Calcitriol results in increased activity of [VDR protein co-treated with RXRA protein]] which results in increased expression of CYP24A1 mRNA]; RELA protein promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; saracatinib inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; tamibarotene inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; Tetradecanoylphorbol Acetate promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; Tretinoin inhibits the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; trichostatin A promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]; trichostatin A promotes the reaction [Valproic Acid promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]]; U 0126 inhibits the reaction [Calcitriol promotes the reaction [NCOR2 protein binds to CYP24A1 mRNA]]; U 0126 inhibits the reaction [Calcitriol promotes the reaction [VDR protein binds to CYP24A1 mRNA]]; Valproic Acid promotes the reaction [[Calcitriol co-treated with VDR protein] results in increased expression of CYP24A1 mRNA]; Valproic Acid promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]PMID:15489543 PMID:15538745 PMID:15867263 PMID:15919092 PMID:15955619 PMID:16289102 PMID:16824767 PMID:18180267 PMID:19106115 PMID:19244278 PMID:19667161 PMID:20206692 PMID:20371703 PMID:21115105 PMID:21592394 PMID:21917910 PMID:22337913 PMID:22466564 PMID:24792400 PMID:29524502 PMID:33033332
Cyp24a1multiple interactionsISOCyp24a1 (Rattus norvegicus)6480464CTD[Calcium co-treated with Calcitriol] affects the expression of CYP24A1 mRNA; [Ketoconazole co-treated with Calcitriol] results in increased expression of CYP24A1 mRNA; Ketoconazole inhibits the reaction [Calcitriol results in increased activity of CYP24A1 protein]PMID:15913539 PMID:16483768
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