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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737323
Species: Homo sapiens
RGD Object: Gene
Symbol: ACE
Name: angiotensin I converting enzyme
Acc ID: CHEBI:30563
Term: silicon dioxide
Definition: A silicon oxide made up of linear triatomic molecules in which a silicon atom is covalently bonded to two oxygens.
Chemical ID: MESH:D012822
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ACEincreases expressionISOAce (Mus musculus)6480464CTDSilicon Dioxide results in increased expression of ACE mRNA; Silicon Dioxide results in increased expression of ACE proteinPMID:33007385
ACEmultiple interactionsISOAce (Mus musculus)6480464CTD7-Ala-angiotensin (1-7) promotes the reaction [Silicon Dioxide results in increased expression of ACE protein]; ACE protein affects the reaction [Silicon Dioxide results in decreased abundance of angiotensin I (1-7)]; ACE protein affects the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]; ACE protein affects the reaction [Silicon Dioxide results in decreased expression of ACE2 protein]; ACE protein affects the reaction [Silicon Dioxide results in decreased expression of AGT protein alternative form]; ACE protein affects the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]; ACE protein affects the reaction [Silicon Dioxide results in decreased expression of MAS1 protein]; ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACE mRNA]; ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACE protein]; ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]; ACE protein affects the reaction [Silicon Dioxide results in increased expression of AGT protein]; ACE protein affects the reaction [Silicon Dioxide results in increased expression of AGTR1 protein]; ACE protein affects the reaction [Silicon Dioxide results in increased expression of COL3A1 protein]; ACE protein affects the reaction [Silicon Dioxide results in increased expression of VIM protein]; ACE2 protein affects the reaction [Silicon Dioxide results in increased expression of ACE mRNA]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of ACE mRNA]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of ACE protein]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACE mRNA]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACE protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of COL3A1 protein]]; goralatide affects the reaction [ACE protein affects the reaction [Silicon Dioxide results in increased expression of VIM protein]]; goralatide affects the reaction [ACE2 protein affects the reaction [Silicon Dioxide results in increased expression of ACE mRNA]]; goralatide inhibits the reaction [Silicon Dioxide results in increased expression of ACE mRNA]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of ACE mRNA]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of ACE protein]PMID:33007385
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