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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737309
Species: Homo sapiens
RGD Object: Gene
Symbol: PPARA
Name: peroxisome proliferator activated receptor alpha
Acc ID: CHEBI:77013
Term: beta-naphthoflavone
Definition: An extended flavonoid resulting from the formal fusion of a benzene ring with the f side of flavone.
Chemical ID: MESH:D019324
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPARAincreases expressionISOPpara (Mus musculus)6480464CTDbeta-Naphthoflavone results in increased expression of PPARA mRNA; beta-Naphthoflavone results in increased expression of PPARA proteinPMID:21849270
PPARAmultiple interactionsISOPpara (Rattus norvegicus)6480464CTD[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PPARA mRNAPMID:18164116
PPARAmultiple interactionsISOPpara (Mus musculus)6480464CTDAHR affects the reaction [beta-Naphthoflavone results in increased expression of PPARA mRNA]; AHR affects the reaction [beta-Naphthoflavone results in increased expression of PPARA protein]; alpha-naphthoflavone inhibits the reaction [beta-Naphthoflavone results in increased expression of PPARA protein]; BMAL1 affects the reaction [beta-Naphthoflavone results in increased expression of PPARA mRNA]PMID:21849270
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