GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | PPARA | decreases expression | EXP | | 6480464 | CTD | Glucose results in decreased expression of PPARA mRNA; Glucose results in decreased expression of PPARA protein | PMID:16600694 PMID:23647015 | PPARA | multiple interactions | EXP | | 6480464 | CTD | [Bezafibrate binds to and results in increased activity of PPARA protein] which results in decreased abundance of Glucose; [osteum co-treated with Palmitic Acid co-treated with Glucose co-treated with INS protein co-treated with TNF protein co-treated with IL1B protein co-treated with TNF protein] results in decreased expression of PPARA mRNA; Allopurinol inhibits the reaction [Glucose results in decreased expression of PPARA protein]; Quercetin inhibits the reaction [Glucose results in decreased expression of PPARA protein]; TXNIP mRNA promotes the reaction [Glucose results in decreased expression of PPARA protein] | PMID:20404010 PMID:23647015 PMID:32613381 | PPARA | affects abundance | ISO | Ppara (Mus musculus) | 6480464 | CTD | PPARA protein affects the abundance of Glucose | PMID:20059764 | PPARA | affects expression | ISO | Ppara (Rattus norvegicus) | 6480464 | CTD | Glucose affects the expression of PPARA mRNA | PMID:24349266 | PPARA | affects metabolic processing | ISO | Ppara (Mus musculus) | 6480464 | CTD | PPARA protein affects the metabolism of Glucose | PMID:16777972 | PPARA | decreases expression | ISO | Ppara (Rattus norvegicus) | 6480464 | CTD | Glucose results in decreased expression of PPARA protein | PMID:23647015 PMID:31063766 | PPARA | decreases expression | ISO | Ppara (Mus musculus) | 6480464 | CTD | Glucose results in decreased expression of PPARA protein | PMID:23090186 | PPARA | multiple interactions | ISO | Ppara (Rattus norvegicus) | 6480464 | CTD | [pirinixic acid binds to and results in increased activity of PPARA protein] which affects the metabolism of Glucose; [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased susceptibility to Glucose; Allopurinol inhibits the reaction [Glucose results in decreased expression of PPARA protein]; HET0016 inhibits the reaction [naringenin inhibits the reaction [Glucose results in decreased expression of PPARA protein]]; naringenin inhibits the reaction [Glucose results in decreased expression of PPARA protein]; PPARA protein promotes the reaction [Glucose results in increased secretion of INS1 protein]; Quercetin inhibits the reaction [Glucose results in decreased expression of PPARA protein]; TXNIP mRNA promotes the reaction [Glucose results in decreased expression of PPARA protein] | PMID:15878969 PMID:18469201 PMID:18854422 PMID:23647015 PMID:31063766 | PPARA | multiple interactions | ISO | Ppara (Mus musculus) | 6480464 | CTD | [Acetylglucosamine co-treated with Glucose] binds to PPARA protein; [Atropine co-treated with Glucose] binds to PPARA protein; [Budesonide co-treated with Glucose] binds to PPARA protein; [Enalapril co-treated with Glucose] binds to PPARA protein; [gamma-Aminobutyric Acid co-treated with Glucose] binds to PPARA protein; [gedunin co-treated with Glucose] binds to PPARA protein; [GW 7647 binds to and results in increased activity of PPARA protein] affects the reaction [Glucose affects the abundance of Calcium]; [Oleylethanolamide binds to and results in increased activity of PPARA protein] affects the reaction [Glucose affects the abundance of Calcium]; [pirinixic acid binds to and results in increased activity of PPARA protein] affects the reaction [Glucose affects the abundance of Calcium]; [Pyrazinamide co-treated with Glucose] binds to PPARA protein; [Saccharin co-treated with Glucose] binds to PPARA protein; [salicylamide co-treated with Glucose] binds to PPARA protein; [Tolazoline co-treated with Glucose] binds to PPARA protein; [Tolmetin co-treated with Glucose] binds to PPARA protein; Acetylglucosamine inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Atorvastatin promotes the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Atropine inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Budesonide inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Enalapril inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Fenofibrate promotes the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; gamma-Aminobutyric Acid inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; gedunin inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]; PPARA protein promotes the reaction [pirinixic acid results in decreased abundance of Glucose]; Pravastatin promotes the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Pyrazinamide inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Resveratrol inhibits the reaction [Glucose results in decreased expression of PPARA protein]; Saccharin inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; salicylamide inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Tolazoline inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Tolmetin inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]] | PMID:18812576 PMID:19017711 PMID:20059764 PMID:23090186 | | ||||||||||||||||||||||
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