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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737309
Species: Homo sapiens
RGD Object: Gene
Symbol: PPARA
Name: peroxisome proliferator activated receptor alpha
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPARAdecreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of PPARA mRNA; Arsenic Trioxide results in decreased expression of PPARA proteinPMID:21257625 PMID:22521957
PPARAincreases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of PPARA proteinPMID:30677399
PPARAmultiple interactionsEXP 6480464CTD3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased expression of PPARA protein]; MK-886 inhibits the reaction [Arsenic Trioxide results in increased expression of PPARA protein]; Taurine inhibits the reaction [Arsenic Trioxide results in increased expression of PPARA protein]PMID:30677399
PPARAdecreases expressionISOPpara (Mus musculus)6480464CTDArsenic Trioxide results in decreased expression of PPARA mRNAPMID:30237538
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