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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737309
Species: Homo sapiens
RGD Object: Gene
Symbol: PPARA
Name: peroxisome proliferator activated receptor alpha
Acc ID: CHEBI:28689
Term: dehydroepiandrosterone
Definition: An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.
Chemical ID: MESH:D003687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPARAincreases activityEXP 6480464CTDDehydroepiandrosterone results in increased activity of PPARA proteinPMID:18079279
PPARAdecreases phosphorylationISOPpara (Rattus norvegicus)6480464CTDDehydroepiandrosterone results in decreased phosphorylation of PPARA proteinPMID:18079279
PPARAincreases activityISOPpara (Rattus norvegicus)6480464CTDDehydroepiandrosterone results in increased activity of PPARA proteinPMID:18079279
PPARAincreases expressionISOPpara (Rattus norvegicus)6480464CTDDehydroepiandrosterone results in increased expression of PPARA mRNA; Dehydroepiandrosterone results in increased expression of PPARA proteinPMID:18079279
PPARAmultiple interactionsISOPpara (Rattus norvegicus)6480464CTD[Dehydroepiandrosterone results in increased expression of PPP2CA mRNA] which results in decreased phosphorylation of PPARA protein; Okadaic Acid inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of PPARA protein]; Okadaic Acid inhibits the reaction [Dehydroepiandrosterone results in increased activity of PPARA protein]PMID:18079279
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