GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | PPARA | affects binding | EXP | | 6480464 | CTD | Linoleic Acid binds to PPARA protein | PMID:23843199 PMID:35752307 | PPARA | increases activity | EXP | | 6480464 | CTD | Linoleic Acid results in increased activity of PPARA protein | PMID:25786526 | PPARA | increases expression | EXP | | 6480464 | CTD | Linoleic Acid results in increased expression of PPARA mRNA; Linoleic Acid results in increased expression of PPARA protein | PMID:11172467 | PPARA | multiple interactions | EXP | | 6480464 | CTD | [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased oxidation of Linoleic Acid; Linoleic Acid affects the reaction [PPARA protein binds to CREBBP protein]; Linoleic Acid binds to and results in increased activity of PPARA protein; Linoleic Acid promotes the reaction [PPARA protein binds to NCOA1 protein]; Linoleic Acid promotes the reaction [PPARA protein binds to NCOA2 protein] | PMID:10403814 PMID:15491415 PMID:16731579 PMID:19263263 PMID:20404010 | PPARA | affects abundance | ISO | Ppara (Mus musculus) | 6480464 | CTD | PPARA protein affects the abundance of Linoleic Acid | PMID:23619606 | PPARA | increases expression | ISO | Ppara (Rattus norvegicus) | 6480464 | CTD | Linoleic Acid results in increased expression of PPARA mRNA | PMID:23056435 | PPARA | increases expression | ISO | Ppara (Mus musculus) | 6480464 | CTD | Linoleic Acid results in increased expression of PPARA mRNA | PMID:18154422 | PPARA | multiple interactions | ISO | Ppara (Mus musculus) | 6480464 | CTD | Diethylhexyl Phthalate inhibits the reaction [PPARA protein affects the abundance of Linoleic Acid]; Linoleic Acid binds to and results in increased activity of PPARA protein | PMID:16731579 PMID:23619606 | |
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