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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737309
Species: Homo sapiens
RGD Object: Gene
Symbol: PPARA
Name: peroxisome proliferator activated receptor alpha
Acc ID: CHEBI:17351
Term: linoleic acid
Definition: An octadecadienoic acid in which the two double bonds are at positions 9 and 12 and have Z (cis) stereochemistry.
Chemical ID: MESH:D019787
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPARAaffects bindingEXP 6480464CTDLinoleic Acid binds to PPARA proteinPMID:23843199 PMID:35752307
PPARAincreases activityEXP 6480464CTDLinoleic Acid results in increased activity of PPARA proteinPMID:25786526
PPARAincreases expressionEXP 6480464CTDLinoleic Acid results in increased expression of PPARA mRNA; Linoleic Acid results in increased expression of PPARA proteinPMID:11172467
PPARAmultiple interactionsEXP 6480464CTD[Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased oxidation of Linoleic Acid; Linoleic Acid affects the reaction [PPARA protein binds to CREBBP protein]; Linoleic Acid binds to and results in increased activity of PPARA protein; Linoleic Acid promotes the reaction [PPARA protein binds to NCOA1 protein]; Linoleic Acid promotes the reaction [PPARA protein binds to NCOA2 protein]PMID:10403814 PMID:15491415 PMID:16731579 PMID:19263263 PMID:20404010
PPARAaffects abundanceISOPpara (Mus musculus)6480464CTDPPARA protein affects the abundance of Linoleic AcidPMID:23619606
PPARAincreases expressionISOPpara (Rattus norvegicus)6480464CTDLinoleic Acid results in increased expression of PPARA mRNAPMID:23056435
PPARAincreases expressionISOPpara (Mus musculus)6480464CTDLinoleic Acid results in increased expression of PPARA mRNAPMID:18154422
PPARAmultiple interactionsISOPpara (Mus musculus)6480464CTDDiethylhexyl Phthalate inhibits the reaction [PPARA protein affects the abundance of Linoleic Acid]; Linoleic Acid binds to and results in increased activity of PPARA proteinPMID:16731579 PMID:23619606
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