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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737243
Species: Homo sapiens
RGD Object: Gene
Symbol: AKAP12
Name: A-kinase anchoring protein 12
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKAP12affects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of AKAP12 promoterPMID:27901495
AKAP12decreases methylationEXP 6480464CTDBenzo(a)pyrene results in decreased methylation of AKAP12 exonPMID:27901495
AKAP12increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of AKAP12 mRNA; Benzo(a)pyrene results in increased expression of AKAP12 proteinPMID:20106945 PMID:21632981 PMID:21871943 PMID:22316170 PMID:26238291 PMID:32234424 PMID:32717239 PMID:35870112
AKAP12decreases expressionISOAkap12 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of AKAP12 mRNAPMID:19770486
AKAP12increases expressionISOAkap12 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of AKAP12 mRNAPMID:32417428
AKAP12increases methylationISOAkap12 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased methylation of AKAP12 intronPMID:27901495
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