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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737239
Species: Homo sapiens
RGD Object: Gene
Symbol: FLG
Name: filaggrin
Acc ID: CHEBI:2761
Term: dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate
Definition: A hydrate that is the trihydrate form of dipotassium bis[mu-tartrato(4-)]diantimonate(2-).
Chemical ID: MESH:D000966
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FLGdecreases expressionEXP 6480464CTDAntimony Potassium Tartrate results in decreased expression of FLG mRNAPMID:28713220
FLGmultiple interactionsEXP 6480464CTD2-tert-butyl-9-fluoro-3,6-dihydro-7H-benz(h)imidazo(4,5-f)isoquinoline-7-one promotes the reaction [[Antimony Potassium Tartrate results in increased abundance of antimonite] which results in decreased expression of FLG mRNA]; [Antimony Potassium Tartrate results in increased abundance of antimonite] which results in decreased expression of FLG mRNA; Hydrocortisone inhibits the reaction [[Antimony Potassium Tartrate results in increased abundance of antimonite] which results in decreased expression of FLG mRNA]; U 0126 inhibits the reaction [[Antimony Potassium Tartrate results in increased abundance of antimonite] which results in decreased expression of FLG mRNA]PMID:32076005
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