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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737222
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
Acc ID: CHEBI:5132
Term: flutamide
Definition: A (trifluoromethyl)benzene that has formula C11H11F3N2O3.
Chemical ID: MESH:D005485
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp17a1increases expressionEXP 6480464CTDFlutamide results in increased expression of CYP17A1 mRNAPMID:11509743
Cyp17a1decreases expressionISOCyp17a1 (Rattus norvegicus)6480464CTDFlutamide results in decreased expression of CYP17A1 mRNAPMID:24136188
Cyp17a1increases expressionISOCyp17a1 (Rattus norvegicus)6480464CTDFlutamide results in increased expression of CYP17A1 mRNAPMID:14967917 PMID:19299419 PMID:21525395 PMID:26485406 PMID:32738380
Cyp17a1multiple interactionsISOCyp17a1 (Rattus norvegicus)6480464CTD[Dienestrol co-treated with Flutamide] results in increased expression of CYP17A1 mRNAPMID:32738380
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