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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737222
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
Acc ID: CHEBI:15930
Term: atrazine
Definition: A diamino-1,3,5-triazine that is 1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6 while one of hydrogens of each amino group is replaced respectively by an ethyl and a propan-2-yl group.
Chemical ID: MESH:D001280
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp17a1decreases expressionEXP 6480464CTDAtrazine results in decreased expression of CYP17A1 mRNAPMID:23376530 PMID:23591565 PMID:33463082
Cyp17a1increases expressionEXP 6480464CTDAtrazine results in increased expression of CYP17A1 mRNAPMID:36831314
Cyp17a1decreases expressionISOCyp17a1 (Rattus norvegicus)6480464CTDAtrazine results in decreased expression of CYP17A1 mRNAPMID:19541795 PMID:29710542
Cyp17a1increases expressionISOCyp17a1 (Rattus norvegicus)6480464CTDAtrazine results in increased expression of CYP17A1 mRNA; Atrazine results in increased expression of CYP17A1 proteinPMID:20667998 PMID:23200735
Cyp17a1multiple interactionsISOCyp17a1 (Rattus norvegicus)6480464CTD[Atrazine co-treated with Bucladesine] results in increased expression of CYP17A1 mRNA; Carnitine inhibits the reaction [Atrazine results in decreased expression of CYP17A1 mRNA]; Quercetin inhibits the reaction [[Atrazine co-treated with Bucladesine] results in increased expression of CYP17A1 mRNA]; Quercetin inhibits the reaction [Atrazine results in decreased expression of CYP17A1 mRNA]; Quercetin inhibits the reaction [Atrazine results in increased expression of CYP17A1 mRNA]PMID:23200735 PMID:29710542
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