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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737217
Species: Homo sapiens
RGD Object: Gene
Symbol: LHCGR
Name: luteinizing hormone/choriogonadotropin receptor
Acc ID: CHEBI:15930
Term: atrazine
Definition: A diamino-1,3,5-triazine that is 1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6 while one of hydrogens of each amino group is replaced respectively by an ethyl and a propan-2-yl group.
Chemical ID: MESH:D001280
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
LHCGRmultiple interactionsEXP 6480464CTDAtrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]PMID:28859905
LHCGRdecreases expressionISOLhcgr (Rattus norvegicus)6480464CTDAtrazine results in decreased expression of LHCGR mRNAPMID:19541795 PMID:22285353
LHCGRincreases expressionISOLhcgr (Rattus norvegicus)6480464CTDAtrazine results in increased expression of LHCGR mRNAPMID:23200735
LHCGRmultiple interactionsISOLhcgr (Rattus norvegicus)6480464CTD[Atrazine co-treated with Bucladesine] results in increased expression of LHCGR mRNA; [Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of AREG mRNA]; [Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of EREG mRNA]; [Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of PGR mRNA]; Atrazine inhibits the reaction [Chorionic Gonadotropin results in increased expression of LHCGR mRNA]; Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]; Atrazine promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of LHCGR mRNA]; Quercetin inhibits the reaction [[Atrazine co-treated with Bucladesine] results in increased expression of LHCGR mRNA]; Quercetin inhibits the reaction [Atrazine results in increased expression of LHCGR mRNA]; U 0126 inhibits the reaction [[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of AREG mRNA]]; U 0126 inhibits the reaction [[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of EREG mRNA]]; U 0126 inhibits the reaction [[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of PGR mRNA]]; U 0126 inhibits the reaction [Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]]PMID:23200735 PMID:23583632 PMID:26923738
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