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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737208
Species: Mus musculus
RGD Object: Gene
Symbol: Chrm3
Name: cholinergic receptor, muscarinic 3, cardiac
Acc ID: CHEBI:15355
Term: acetylcholine
Definition: Actylcholine is an ester of acetic acid and choline, which acts as a neurotransmitter.
Chemical ID: MESH:D000109
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrm3increases activityEXP 6480464CTDAcetylcholine results in increased activity of CHRM3 proteinPMID:15964566
Chrm3increases response to substanceEXP 6480464CTDCHRM3 protein results in increased susceptibility to AcetylcholinePMID:15964566 PMID:19407017
Chrm3affects bindingISOChrm3 (Rattus norvegicus)6480464CTDAcetylcholine binds to CHRM3 proteinPMID:12435818
Chrm3affects bindingISOCHRM3 (Homo sapiens)6480464CTDAcetylcholine binds to CHRM3 protein; CHRM3 protein binds to AcetylcholinePMID:10069518 PMID:9224827 PMID:9495826
Chrm3increases activityISOChrm3 (Rattus norvegicus)6480464CTDAcetylcholine results in increased activity of CHRM3 proteinPMID:11755166
Chrm3increases activityISOCHRM3 (Homo sapiens)6480464CTDAcetylcholine results in increased activity of CHRM3 proteinPMID:31830555
Chrm3multiple interactionsISOChrm3 (Rattus norvegicus)6480464CTDPregnenolone inhibits the reaction [Acetylcholine binds to CHRM3 protein]; Progesterone inhibits the reaction [Acetylcholine binds to CHRM3 protein]; WIN 62577 analog inhibits the reaction [Acetylcholine binds to CHRM3 protein]; WIN 62577 promotes the reaction [Acetylcholine binds to CHRM3 protein]PMID:12435818 PMID:15900516
Chrm3multiple interactionsISOCHRM3 (Homo sapiens)6480464CTDAcetylcholine binds to and results in increased activity of CHRM3 protein; brucine analog affects the reaction [Acetylcholine binds to CHRM3 protein]; brucine N-oxide promotes the reaction [Acetylcholine binds to CHRM3 protein]; brucine promotes the reaction [Acetylcholine binds to CHRM3 protein]; N-chloromethylbrucine promotes the reaction [Acetylcholine binds to CHRM3 protein]; N-chloromethylbrucine promotes the reaction [Acetylcholine results in increased activity of CHRM3 protein]PMID:10069518 PMID:10101037 PMID:9224827 PMID:9495826
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