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GENE - TERM ANNOTATION REPORT

RGD ID: 737167
Species: Homo sapiens
RGD Object: Gene
Symbol: GTF2A2
Name: general transcription factor IIA subunit 2
Acc ID: GO:0051123
Term: RNA polymerase II preinitiation complex assembly
Definition: The formation of a large multiprotein-DNA complex that self-assembles on gene promoter through the sequential recruitment of the general initiation factors that compose the preinitiation complex (PIC) (which may include TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIIH complexes). The PIC engages RNA polymerase II on its DNA template strand and sparks polymerization of the first few RNA nucleotides of the nascent transcript, of which 8 are base-paired with the DNA template within a DNA bubble. PIC assembly may result in a pause step, which marks the end of the PIC assembly and may be followed by promoter clearance (exact synonym: promoter escape). For RNA polymerase II PIC assembly is preceded by the formation of a nucleosome-free region that allows the transcription machinery to access the promoter DNA.
Definition Source(s): GOC:txnOH, PMID:15020047, PMID:31300188
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GTF2A2involved_inIDA 150520179BHF-UCL PMID:7958899 PMID:8626665

PMID:7958899 PMID:8626665
GTF2A2involved_inNAS 150520179ComplexPortal PMID:8870495

PMID:8870495
GTF2A2involved_inIBAPANTHER:PTN000103450 or SGD:S000001541 or UniProtKB:P52657150520179GO_Central GO_REF:0000033
GTF2A2involved_inIEAPANTHER:PTHR10966:SF0150520179TreeGrafter GO_REF:0000118
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