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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737155
Species: Homo sapiens
RGD Object: Gene
Symbol: FOXO1
Name: forkhead box O1
Acc ID: CHEBI:28694
Term: copper atom
Definition: A copper group element atom that has formula Cu.
Chemical ID: MESH:D003300
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FOXO1affects localizationEXP 6480464CTDCopper affects the localization of FOXO1 proteinPMID:16973122
FOXO1increases phosphorylationEXP 6480464CTDCopper results in increased phosphorylation of FOXO1 proteinPMID:16973122
FOXO1multiple interactionsEXP 6480464CTD[Chelating Agents binds to Copper] which results in increased expression of FOXO1 mRNA; Wortmannin inhibits the reaction [Copper affects the localization of FOXO1 protein]; Wortmannin inhibits the reaction [Copper results in increased phosphorylation of FOXO1 protein]PMID:16973122 PMID:30911355
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