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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737111
Species: Homo sapiens
RGD Object: Gene
Symbol: EGR1
Name: early growth response 1
Acc ID: CHEBI:9753
Term: troglitazone
Definition: A chromane that has formula C24H27NO5S.
Chemical ID: MESH:C057693
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EGR1decreases expressionEXP 6480464CTDtroglitazone results in decreased expression of EGR1 mRNAPMID:19631733 PMID:25572481
EGR1increases activityEXP 6480464CTDtroglitazone results in increased activity of EGR1 proteinPMID:12475986
EGR1increases expressionEXP 6480464CTDtroglitazone results in increased expression of EGR1 mRNA; troglitazone results in increased expression of EGR1 proteinPMID:12475986 PMID:15064713 PMID:16079301 PMID:21461570
EGR1multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [troglitazone results in increased expression of EGR1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [troglitazone results in increased expression of EGR1 protein]; [EGR1 protein binds to GDF15 promoter] affects the reaction [troglitazone results in increased expression of GDF15]; EGR1 protein promotes the reaction [troglitazone results in increased expression of ATF3 mRNA]; troglitazone results in increased expression of and results in increased stability of EGR1 mRNAPMID:12475986 PMID:14662774 PMID:16079301
EGR1decreases expressionISOEgr1 (Mus musculus)6480464CTDtroglitazone results in decreased expression of EGR1 mRNA; troglitazone results in decreased expression of EGR1 proteinPMID:12468449 PMID:28973697
EGR1multiple interactionsISOEgr1 (Rattus norvegicus)6480464CTDtroglitazone inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased activity of EGR1 protein]; troglitazone inhibits the reaction [Oxygen deficiency results in increased expression of EGR1 mRNA]PMID:12468449
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