GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | EGR1 | decreases expression | EXP | | 6480464 | CTD | Quercetin results in decreased expression of EGR1 mRNA | PMID:15309432 | EGR1 | increases expression | EXP | | 6480464 | CTD | Quercetin metabolite results in increased expression of EGR1 mRNA; Quercetin results in increased expression of EGR1 mRNA | PMID:21632981 PMID:25645941 PMID:27514524 PMID:30152185 PMID:36982678 | EGR1 | increases expression | ISO | Egr1 (Mus musculus) | 6480464 | CTD | Quercetin results in increased expression of EGR1 protein | PMID:22174042 | EGR1 | increases expression | ISO | Egr1 (Rattus norvegicus) | 6480464 | CTD | Quercetin results in increased expression of EGR1 mRNA; Quercetin results in increased expression of EGR1 protein | PMID:19798679 PMID:22174042 | EGR1 | multiple interactions | ISO | Egr1 (Rattus norvegicus) | 6480464 | CTD | N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Quercetin results in increased expression of EGR1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Quercetin results in increased expression of EGR1 protein]; PRKACA protein affects the reaction [Quercetin results in increased expression of EGR1 mRNA]; PRKACA protein affects the reaction [Quercetin results in increased expression of EGR1 protein]; Quercetin promotes the reaction [EGR1 protein binds to GCLC promoter]; SB 203580 inhibits the reaction [Quercetin results in increased expression of EGR1 mRNA]; SB 203580 inhibits the reaction [Quercetin results in increased expression of EGR1 protein] | PMID:19798679 PMID:22174042 | |
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