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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737111
Species: Homo sapiens
RGD Object: Gene
Symbol: EGR1
Name: early growth response 1
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EGR1affects expressionEXP 6480464CTDValproic Acid affects the expression of EGR1 mRNAPMID:25979313
EGR1decreases expressionEXP 6480464CTDValproic Acid results in decreased expression of EGR1 mRNAPMID:24935251 PMID:28001369
EGR1decreases methylationEXP 6480464CTDValproic Acid results in decreased methylation of EGR1 genePMID:28853863 PMID:29201983
EGR1increases expressionEXP 6480464CTDValproic Acid results in increased expression of EGR1 mRNAPMID:23179753 PMID:24383497 PMID:24935251 PMID:27188386 PMID:29154799 PMID:29501571
EGR1affects expressionISOEgr1 (Mus musculus)6480464CTDValproic Acid affects the expression of EGR1 mRNAPMID:17963808
EGR1decreases expressionISOEgr1 (Mus musculus)6480464CTDValproic Acid results in decreased expression of EGR1 mRNAPMID:29261810
EGR1decreases expressionISOEgr1 (Rattus norvegicus)6480464CTDValproic Acid results in decreased expression of EGR1 mRNAPMID:29427782
EGR1increases expressionISOEgr1 (Mus musculus)6480464CTDValproic Acid results in increased expression of EGR1 mRNAPMID:20546886
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