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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737014
Species: Mus musculus
RGD Object: Gene
Symbol: Tlr4
Name: toll-like receptor 4
Acc ID: CHEBI:34682
Term: diazinon
Definition: A member of the class of pyrimidines that is pyrimidine carrying an isopropyl group at position 2, a methyl group at position 6 and a (diethoxyphosphorothioyl)oxy group at position 4.
Chemical ID: MESH:D003976
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tlr4increases response to substanceEXP 6480464CTDTLR4 protein mutant form results in increased susceptibility to DiazinonPMID:22428454
Tlr4multiple interactionsEXP 6480464CTD[TLR4 protein mutant form results in increased susceptibility to Diazinon] which results in decreased expression of BDNF mRNA; [TLR4 protein mutant form results in increased susceptibility to Diazinon] which results in decreased expression of NGF mRNA; [TLR4 protein mutant form results in increased susceptibility to Diazinon] which results in increased expression of BAX mRNAPMID:22428454
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