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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737014
Species: Mus musculus
RGD Object: Gene
Symbol: Tlr4
Name: toll-like receptor 4
Acc ID: CHEBI:32497
Term: thioacetamide
Definition: A thiocarboxamide consiting of acetamide having the oxygen replaced by sulfur.
Chemical ID: MESH:D013853
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tlr4increases expressionISOTlr4 (Rattus norvegicus)6480464CTDThioacetamide results in increased expression of TLR4 mRNA; Thioacetamide results in increased expression of TLR4 proteinPMID:30500344 PMID:33503444 PMID:33677747 PMID:34492290 PMID:34792689
Tlr4multiple interactionsISOTlr4 (Rattus norvegicus)6480464CTDAM 1241 inhibits the reaction [Thioacetamide results in increased expression of TLR4 mRNA]; chrysin inhibits the reaction [Thioacetamide results in increased expression of TLR4 mRNA]; Silymarin inhibits the reaction [Thioacetamide results in increased expression of TLR4 mRNA]PMID:30500344 PMID:33503444
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