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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737014
Species: Mus musculus
RGD Object: Gene
Symbol: Tlr4
Name: toll-like receptor 4
Acc ID: CHEBI:90369
Term: 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Definition: A member of the class of carbazoles that is 2,3,4,9-tetrahydro-1H-carbazole which is substituted at position 1 by an aminocarbohyl group and at position 6 by a chlorine.
Chemical ID: MESH:C550547
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tlr4multiple interactionsISOTLR4 (Homo sapiens)6480464CTD6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TLR4 mRNA]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of TLR4 protein]PMID:37436145
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