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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737013
Species: Homo sapiens
RGD Object: Gene
Symbol: TLR4
Name: toll like receptor 4
Acc ID: CHEBI:8426
Term: probenecid
Definition: A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Chemical ID: MESH:D011339
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TLR4multiple interactionsISOTlr4 (Mus musculus)6480464CTD1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of TLR4 mRNA]; [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of TLR4 mRNAPMID:25406165
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