GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | TLR4 | increases expression | EXP | | 6480464 | CTD | Atorvastatin results in increased expression of TLR4 protein | PMID:16387846 | TLR4 | multiple interactions | EXP | | 6480464 | CTD | [Atorvastatin co-treated with Enalapril] results in decreased expression of TLR4 mRNA; [Atorvastatin co-treated with Enalapril] results in decreased expression of TLR4 protein; [Atorvastatin co-treated with Telmisartan] results in decreased expression of TLR4 mRNA; [Atorvastatin co-treated with Telmisartan] results in decreased expression of TLR4 protein | PMID:20524934 | TLR4 | decreases expression | ISO | Tlr4 (Rattus norvegicus) | 6480464 | CTD | Atorvastatin results in decreased expression of TLR4 mRNA; Atorvastatin results in decreased expression of TLR4 protein | PMID:27883937 | TLR4 | multiple interactions | ISO | Tlr4 (Rattus norvegicus) | 6480464 | CTD | Atorvastatin inhibits the reaction [[Dietary Fats co-treated with Ergocalciferols] results in increased expression of TLR4 mRNA]; Atorvastatin inhibits the reaction [[Dietary Fats co-treated with Ergocalciferols] results in increased expression of TLR4 protein]; Atorvastatin inhibits the reaction [Paraquat results in increased expression of TLR4 mRNA]; Atorvastatin inhibits the reaction [Paraquat results in increased expression of TLR4 protein] | PMID:27883937 PMID:38213245 | | ||||||||||||||||||||||
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