GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | TLR4 | increases expression | EXP | | 6480464 | CTD | Paraquat results in increased expression of TLR4 mRNA; Paraquat results in increased expression of TLR4 protein | PMID:27890776 PMID:34097952 PMID:34463846 PMID:34681664 | TLR4 | multiple interactions | EXP | | 6480464 | CTD | epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of TLR4 protein]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Paraquat results in increased expression of TLR4 protein]; TNC protein affects the reaction [Paraquat results in increased expression of TLR4 protein] | PMID:27890776 PMID:34463846 | TLR4 | increases expression | ISO | Tlr4 (Rattus norvegicus) | 6480464 | CTD | Paraquat results in increased expression of TLR4 mRNA; Paraquat results in increased expression of TLR4 protein | PMID:27883937 PMID:30967525 | TLR4 | increases expression | ISO | Tlr4 (Mus musculus) | 6480464 | CTD | Paraquat results in increased expression of TLR4 mRNA; Paraquat results in increased expression of TLR4 protein | PMID:23969119 PMID:27890776 PMID:28131803 PMID:29441825 PMID:30584891 PMID:31299241 PMID:34463846 PMID:36031164 | TLR4 | increases response to substance | ISO | Tlr4 (Mus musculus) | 6480464 | CTD | TLR4 results in increased susceptibility to Paraquat | PMID:23969119 | TLR4 | multiple interactions | ISO | Tlr4 (Rattus norvegicus) | 6480464 | CTD | Atorvastatin inhibits the reaction [Paraquat results in increased expression of TLR4 mRNA]; Atorvastatin inhibits the reaction [Paraquat results in increased expression of TLR4 protein] | PMID:27883937 | TLR4 | multiple interactions | ISO | Tlr4 (Mus musculus) | 6480464 | CTD | Cyclophosphamide inhibits the reaction [Paraquat results in increased expression of TLR4 mRNA]; Dexamethasone inhibits the reaction [Paraquat results in increased expression of TLR4 mRNA]; epigallocatechin gallate inhibits the reaction [Paraquat results in increased expression of TLR4 protein]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Paraquat results in increased expression of TLR4 protein]; HSPD1 protein promotes the reaction [Paraquat results in increased expression of TLR4 protein]; TLR4 gene mutant form inhibits the reaction [Paraquat results in increased expression of BAD protein]; TLR4 gene mutant form inhibits the reaction [Paraquat results in increased expression of IL1B protein]; TLR4 gene mutant form inhibits the reaction [Paraquat results in increased expression of TNF protein]; TLR4 protein affects the reaction [bafilomycin A promotes the reaction [Paraquat results in increased expression of MAP1LC3B protein]]; TLR4 protein affects the reaction [Paraquat results in decreased phosphorylation of MTOR protein]; TLR4 protein affects the reaction [Paraquat results in decreased phosphorylation of ULK1 protein]; TLR4 protein affects the reaction [Paraquat results in increased expression of ATG5 protein]; TLR4 protein affects the reaction [Paraquat results in increased expression of ATG7 protein]; TLR4 protein affects the reaction [Paraquat results in increased expression of MAP1LC3B protein]; TLR4 protein affects the reaction [Paraquat results in increased expression of SQSTM1 protein] | PMID:23969119 PMID:27246695 PMID:27442881 PMID:27890776 PMID:30584891 PMID:36031164 | | ||||||||||||||||||||||
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