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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736975
Species: Mus musculus
RGD Object: Gene
Symbol: Kcnmb1
Name: potassium large conductance calcium-activated channel, subfamily M, beta member 1
Acc ID: CHEBI:41774
Term: tamoxifen
Definition: A stilbenoid that has formula 371.51460.
Chemical ID: MESH:D013629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnmb1multiple interactionsISOKCNMB1 (Homo sapiens)6480464CTDTamoxifen binds to and results in increased activity of KCNMB1 protein; Tamoxifen inhibits the reaction [Glucose inhibits the reaction [[KCNMA1 protein binds to KCNMB1 protein] which results in decreased expression of BCL2 protein]]; Tamoxifen inhibits the reaction [Glucose results in decreased activity of [KCNMA1 protein binds to KCNMB1 protein]]PMID:21413024
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