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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736925
Species: Homo sapiens
RGD Object: Gene
Symbol: GJA1
Name: gap junction protein alpha 1
Acc ID: CHEBI:41072
Term: 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
Definition: An indole that has formula C25H24N4O2.
Chemical ID: MESH:C070515
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GJA1increases expressionISOGja1 (Rattus norvegicus)6480464CTDbisindolylmaleimide I results in increased expression of GJA1 proteinPMID:34283317
GJA1multiple interactionsISOGja1 (Rattus norvegicus)6480464CTDBenzo(a)pyrene inhibits the reaction [bisindolylmaleimide I results in increased expression of GJA1 protein]; bisindolylmaleimide I inhibits the reaction [Benzo(a)pyrene results in decreased expression of GJA1 protein]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of GJA1 mRNA]; bisindolylmaleimide I inhibits the reaction [Phenylephrine results in increased expression of GJA1 protein]; bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of and results in increased degradation of GJA1 protein]PMID:15685554 PMID:16352648 PMID:18445782 PMID:34283317
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