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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736925
Species: Homo sapiens
RGD Object: Gene
Symbol: GJA1
Name: gap junction protein alpha 1
Acc ID: CHEBI:34202
Term: 2,2',4,4',5,5'-hexachlorobiphenyl
Definition: A hexachlorobiphenyl that has formula C12H4Cl6.
Chemical ID: MESH:C014024
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GJA1multiple interactionsEXP 6480464CTD[DDT co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of GJA1 protein; [Dieldrin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of GJA1 proteinPMID:8820588
GJA1affects localizationISOGja1 (Rattus norvegicus)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl affects the localization of GJA1 proteinPMID:18832185
GJA1decreases expressionISOGja1 (Rattus norvegicus)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of GJA1 proteinPMID:11767051 PMID:18832185 PMID:27318803
GJA1multiple interactionsISOGja1 (Rattus norvegicus)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [MAPK1 protein results in increased phosphorylation of GJA1 protein]; 2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [MAPK3 protein results in increased phosphorylation of GJA1 protein]; SPHK1 protein affects the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of GJA1 protein]PMID:18832185 PMID:27318803
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