Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	736914
Species:	Homo sapiens
RGD Object:	Gene
Symbol:	CST3
Name:	cystatin C

Acc ID:	CHEBI:27899
Term:	cisplatin
Definition:	A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID:	MESH:D002945

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
CST3	increases expression	EXP		6480464	CTD	Cisplatin results in increased expression of CST3; Cisplatin results in increased expression of CST3 mRNA	PMID:22525860 PMID:27392435 PMID:27594783
CST3	multiple interactions	EXP		6480464	CTD	[Cisplatin co-treated with jinfukang] results in increased expression of CST3 mRNA; Cimetidine inhibits the reaction [Cisplatin results in increased expression of CST3]; SLC22A2 gene polymorphism inhibits the reaction [Cisplatin results in increased expression of CST3]	PMID:22525860 PMID:27392435
CST3	increases expression	ISO	Cst3 (Rattus norvegicus)	6480464	CTD	Cisplatin results in increased expression of CST3 protein	PMID:29216766
CST3	multiple interactions	ISO	Cst3 (Rattus norvegicus)	6480464	CTD	vanillin inhibits the reaction [Cisplatin results in increased expression of CST3 protein]	PMID:29216766

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