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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736866
Species: Homo sapiens
RGD Object: Gene
Symbol: ABCC3
Name: ATP binding cassette subfamily C member 3
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ABCC3increases activityEXP 6480464CTDDexamethasone results in increased activity of ABCC3 proteinPMID:15979871
ABCC3increases expressionEXP 6480464CTDDexamethasone results in increased expression of ABCC3 mRNA; Dexamethasone results in increased expression of ABCC3 proteinPMID:15979871 PMID:25047013
ABCC3multiple interactionsEXP 6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ABCC3 mRNA; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ABCC3 mRNA; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of ABCC3 mRNA; Dexamethasone promotes the reaction [ABCC3 protein affects the transport of calcein AM]PMID:15979871 PMID:28628672
ABCC3affects expressionISOAbcc3 (Rattus norvegicus)6480464CTDDexamethasone affects the expression of ABCC3 mRNAPMID:15102944
ABCC3decreases expressionISOAbcc3 (Rattus norvegicus)6480464CTDDexamethasone results in decreased expression of ABCC3 mRNA; Dexamethasone results in decreased expression of ABCC3 proteinPMID:15102944 PMID:17522070 PMID:19922765 PMID:20888898
ABCC3increases expressionISOAbcc3 (Rattus norvegicus)6480464CTDDexamethasone results in increased expression of ABCC3 proteinPMID:15908472
ABCC3multiple interactionsISOAbcc3 (Rattus norvegicus)6480464CTDDexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of ABCC3 mRNA]PMID:15205389
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