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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736842
Species: Homo sapiens
RGD Object: Gene
Symbol: HTR2C
Name: 5-hydroxytryptamine receptor 2C
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HTR2Cincreases methylationEXP 6480464CTDbisphenol A results in increased methylation of HTR2C genePMID:31601247
HTR2Cdecreases expressionISOHtr2c (Mus musculus)6480464CTDbisphenol A results in decreased expression of HTR2C mRNAPMID:32156529
HTR2Cdecreases expressionISOHtr2c (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of HTR2C mRNAPMID:25181051 PMID:26186136 PMID:27103539 PMID:29097150 PMID:30816183
HTR2Cincreases expressionISOHtr2c (Mus musculus)6480464CTDbisphenol A results in increased expression of HTR2C mRNAPMID:35598803
HTR2Cincreases methylationISOHtr2c (Rattus norvegicus)6480464CTDbisphenol A results in increased methylation of HTR2C genePMID:28505145
HTR2Cmultiple interactionsISOHtr2c (Rattus norvegicus)6480464CTD[bisphenol A co-treated with Genistein] results in increased methylation of HTR2C genePMID:28505145
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